acetogentin dr mclaughlin tree of life dr allan spreen reviews

'Annona muricata: A comprehensive review on its traditional medicinal uses, phytochemicals, pharmacological activities, mechanisms of action and toxicity'. Coria-Téllez Efigenia Montalvo-Gónzalez Elhadi M. 'Annonaceous Acetogenins: Recent Progress'. ^ a b c Alali, Feras Q Liu, Xiao-Xi McLaughlin, Jerry L (1999).Progress in the Chemistry of Organic Natural Products. ^ Liaw, Chih-Chuang Liou, Jing-Ru Wu, Tung-Ying Chang, Fang-Rong Wu, Yang-Chang (2016).'Acetogenins from Annonaceae: Recent Progress in Isolation, Synthesis and Mechanisms of Action'. 'Recent Progress on the Total Synthesis of Acetogenins from Annonaceae' (PDF). Mechanism of action Īcetogenins inhibit NADH dehydrogenase, a key enzyme in energy metabolism. Purified acetogenins and crude extracts of the common North American pawpaw ( Asimina triloba) or the soursop ( Annona muricata) remain under laboratory studies. Examples of R-groups for selected acetogenins CompoundĪcetogenins have been investigated for their biological properties, but are a concern due to neurotoxicity. These THF rings are located along the hydrocarbon chain, along with a number of oxygenated moieties (hydroxyls, acetoxyls, ketones, epoxides) and/or double bonds. Structurally, acetogenins are a series of C-35/C-37 compounds usually characterized by a long aliphatic chain bearing a terminal methyl-substituted α,β-unsaturated γ-lactone ring, as well as one to three tetrahydrofuran (THF) rings. Structure Acetogenin core unit (mono-THF) Acetogenin terminal lactone ring core unit (unsaturated) Many acetogenins are characterized by neurotoxicity. Over 400 members of this family of compounds have been isolated from 51 different species of plants. They are often terminated with a lactone or butenolide. They are characterized by linear 32- or 34-carbon chains containing oxygenated functional groups including hydroxyls, ketones, epoxides, tetrahydrofurans and tetrahydropyrans. Acetogenins are a class of polyketide natural products found in plants of the family Annonaceae.

Acetogentin dr mclaughlin tree of life dr allan spreen reviews